| Date | Location | Result | |
| Nov 27, 2021 | Worcester, MA | Holy Cross 13, Sacred Heart 10 | Box score |
| Nov 20, 2021 | Staten Island, NY | Duquesne 44, Wagner 0 | Box score |
| Nov 20, 2021 | North Andover, | Bryant 58, Merrimack 14 | Box score |
| Nov 20, 2021 | Brookville, NY | Sacred Heart 38, Long Island 14 | Box score |
| Nov 20, 2021 | New Britain, CT | Central Connecticut 24, Saint Francis 21 | Box score |
| Nov 13, 2021 | Fairfield, Connectic | Sacred Heart 27, Wagner 0 | Box score |
| Nov 13, 2021 | Loretto, Pennsylvani | Saint Francis 22, Merrimack 6 | Box score |
| Nov 13, 2021 | Pittsburgh, Pa. | Duquesne 31, Central Connecticut 27 | Box score |
| Nov 13, 2021 | Smithfield, Rhode Is | Bryant 52, Long Island 7 | Box score |
| Nov 06, 2021 | Staten Island, NY | Merrimack 35, Wagner 26 | Box score |
| Nov 06, 2021 | Loretto, Pennsylvani | Sacred Heart 14, Saint Francis 13 | Box score |
| Nov 06, 2021 | Brookville, N.Y. | Duquesne 34, Long Island 28 | Box score |
| Nov 06, 2021 | New Britain, CT | Central Connecticut 30, Bryant 15 | Box score |
| Oct 30, 2021 | North Andover, Massa | Central Connecticut 49, Merrimack 21 | Box score |
| Oct 30, 2021 | Brookvile, NY | Long Island 28, Wagner 14 | Box score |
| Oct 30, 2021 | Pittsburgh, Pennsylv | Saint Francis 17, Duquesne 10 | Box score |
| Oct 23, 2021 | Staten Island, NY | Bryant 31, Wagner 10 | Box score |
| Oct 23, 2021 | Fairfield, Connectic | Sacred Heart 31, Duquesne 19 | Box score |
| Oct 23, 2021 | New Britain, CT | Long Island 30, Central Connecticut 13 | Box score |
| Oct 16, 2021 | Fairfield, Connectic | Sacred Heart 27, Central Connecticut 17 | Box score |
| Oct 16, 2021 | Brookville, N.Y. | Merrimack 43, Long Island 5 | Box score |
| Oct 16, 2021 | Smithfield, Rhode Is | Bryant 18, Saint Francis 17 | Box score |
| Oct 09, 2021 | Bronx, New York | Fordham 56, Wagner 7 | Box score |
| Oct 09, 2021 | Fairfield, CT | Sacred Heart 20, Merrimack 10 | Box score |
| Oct 09, 2021 | Loretto, Pennsylvani | Saint Francis 55, Long Island 10 | Box score |
| Oct 09, 2021 | Pittsburgh, Pennsylv | Duquesne 39, Bryant 34 | Box score |
| Oct 09, 2021 | New Britain, CT | Columbia 22, Central Connecticut 20 | Box score |
| Oct 02, 2021 | Staten Island, NY | Delaware State 33, Wagner 27 | Box score |
| Oct 02, 2021 | Washington, District | Howard 22, Sacred Heart 17 | Box score |
| Oct. 2, 2021 | BALTIMORE, MD | Saint Francis 27, Morgan St. 14 | Box score |
| Oct 02, 2021 | North Andover, | Duquesne 37, Merrimack 14 | Box score |
| Oct 02, 2021 | Smithfield, Rhode Is | Bryant 36, Brown 29 | Box score |
| Sep 25, 2021 | Philadelphia, Pennsy | Temple 41, Wagner 7 | Box score |
| Sep 25, 2021 | Hanover, New Hampshi | Dartmouth 41, Sacred Heart 3 | Box score |
| Sep 25, 2021 | Loretto, Pennsylvani | Norfolk St. 28, Saint Francis 16 | Box score |
| Sep 25, 2021 | Dover, Del. | Merrimack 47, Delaware State 10 | Box score |
| Sep 25, 2021 | Pittsburgh, Pennsylv | Duquesne 56, Virginia-Lynchburg 7 | Box score |
| Sep 25, 2021 | Miami Gardens, | Miami (FL) 69, Central Connecticut 0 | Box score |
| Sep 25, 2021 | Poughkeepsie, New Yo | Bryant 34, Marist 17 | Box score |
| Sep 18, 2021 | Fairfield, Connectic | Sacred Heart 21, Morgan St. 7 | Box score |
| Sep 18, 2021 | Loretto, Pennsylvani | Saint Francis 39, Wagner 24 | Box score |
| Sep 18, 2021 | Orono, Maine | Maine 31, Merrimack 26 | Box score |
| Sep 18, 2021 | Oxford, OH | Miami (OH) 35, Long Island 7 | Box score |
| Sep 18, 2021 | New Britain, CT | Southeastern La. 56, Central Connecticut 10 | Box score |
| Sep 18, 2021 | Akron, Ohio | Akron 35, Bryant 14 | Box score |
| Sep 11, 2021 | Staten Island, NY | Central Connecticut 21, Wagner 19 | Box score |
| Sep 11, 2021 | Newark, DE | Delaware 27, Saint Francis 10 | Box score |
| Sep 11, 2021 | Worcester, Massachus | Merrimack 35, Holy Cross 21 | Box score |
| Sep 11, 2021 | Morgantown, WV | West Virginia 66, Long Island 0 | Box score |
| Sep 11, 2021 | Athens, Ohio | Duquesne 28, Ohio 26 | Box score |
| Sep 11, 2021 | Smithfield, RI | Bryant 17, Sacred Heart 6 | Box score |
| Sep 04, 2021 | Fairfield, CT | Sacred Heart 21, Bucknell 0 | Box score |
| Sep 04, 2021 | North Andover, Massa | Merrimack 55, St. Anselm 23 | Box score |
| Sep 04, 2021 | Fort Worth, TX | Texas Christian 45, Duquesne 3 | Box score |
| Sep 04, 2021 | Kingston, RI | Rhode Island 45, Bryant 21 | Box score |
| Sep 03, 2021 | Ypsilanti, Mich. | Eastern Michigan 35, Saint Francis 15 | Box score |
| Sep 03, 2021 | New Britain, CT | Southern Conn. St. 28, Central Connecticut 21 | Box score |
| Sep 02, 2021 | Buffalo, | Buffalo 69, Wagner 7 | Box score |
| Sep 02, 2021 | Miami, FL | Fla International 48, Long Island 10 | Box score |